Varaico: Literature-Extracted Genetic Variants

DROSHA

357 papers

RefSeq Summary

This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA...

Pfam Domains

Helical_CED_Droshaaa 718–850UCSCRibonuclease 3, central domain, two antiparallel helical region

Ribonucleas_3_3aa 957–1072UCSCRibonuclease-III-like

Ribonuclease_3aa 1144–1233UCSCRibonuclease III domain

dsrmaa 1261–1332UCSCDouble-stranded RNA binding motif

Gene Aliases

HGNC Name

drosha ribonuclease III

HGNC Previous Symbol

RNASEN

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001382508.1

p.R277C

c.829C>T

Surrounding Variants

4 papers

NM_001382508.1

p.R279C

c.835C>T

6 papers

NM_001382508.1

p.R279L

c.836G>T

1 paper

NM_001382508.1

p.R273I

c.818G>T

2 papers

NM_001382508.1

p.Y281Y

c.843C>T

1 paper

NM_001382508.1

p.D270insFs

c.810dupC

1 paper

NM_001382508.1

p.R271*

c.811C>T

1 paper

NM_001382508.1

p.R283Q

c.848G>A

1 paper

NM_001382508.1

p.D268E

c.804T>G

1 paper

NM_001382508.1

p.D268E

c.804T>A

1 paper

NM_001382508.1

p.Y265*

c.795C>G

1 paper

NM_001382508.1

p.Y265*

c.795C>A

2 papers

NM_001382508.1

p.D262G

c.785A>G