Varaico: Literature-Extracted Genetic Variants

DROSHA

357 papers

RefSeq Summary

This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA...

Pfam Domains

Helical_CED_Droshaaa 718–850UCSCRibonuclease 3, central domain, two antiparallel helical region

Ribonucleas_3_3aa 957–1072UCSCRibonuclease-III-like

Ribonuclease_3aa 1144–1233UCSCRibonuclease III domain

dsrmaa 1261–1332UCSCDouble-stranded RNA binding motif

Gene Aliases

HGNC Name

drosha ribonuclease III

HGNC Previous Symbol

RNASEN

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_001382508.1

p.P211T

c.631C>A

Surrounding Variants

1 paper

NM_001382508.1

p.P211S

c.631C>T

1 paper

NM_001382508.1

p.P216A

c.646C>G

1 paper

NM_001382508.1

p.R219T

c.656G>C

1 paper

NM_001382508.1

p.S200S

c.600T>C

1 paper

NM_001382508.1

p.E223A

c.668A>C

1 paper

NM_001382508.1

p.N198S

c.593A>G

6 papers

NM_001382508.1

p.K226E

c.676A>G

1 paper

NM_001382508.1

p.P194P

c.582C>T

1 paper

NM_001382508.1

p.L193L

c.579G>A

1 paper

NM_001382508.1

p.Y228C

c.683A>G

1 paper

NM_001382508.1

p.D229Y

c.685G>T

1 paper

NM_001382508.1

p.R232S

c.696G>C