Varaico: Literature-Extracted Genetic Variants

DROSHA

357 papers

RefSeq Summary

This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA...

Pfam Domains

Helical_CED_Droshaaa 718–850UCSCRibonuclease 3, central domain, two antiparallel helical region

Ribonucleas_3_3aa 957–1072UCSCRibonuclease-III-like

Ribonuclease_3aa 1144–1233UCSCRibonuclease III domain

dsrmaa 1261–1332UCSCDouble-stranded RNA binding motif

Gene Aliases

HGNC Name

drosha ribonuclease III

HGNC Previous Symbol

RNASEN

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001382508.1

p.A135T

c.403G>A

Surrounding Variants

1 paper

NM_001382508.1

p.A135fs

c.403_404fs

1 paper

NM_001382508.1

p.P136delFs

c.408delA

1 paper

NM_001382508.1

p.A135_P137Fs

c.403_409delinsCCACTTFs

1 paper

NM_001382508.1

p.V132fs

c.394_395fs

1 paper

NM_001382508.1

p.P131insFs

c.392dupC

1 paper

NM_001382508.1

p.N128Y

c.382A>T

2 papers

NM_001382508.1

p.P143insFs

c.428dupC

1 paper

NM_001382508.1

p.M124V

c.370A>G

1 paper

NM_001382508.1

p.P123L

c.368C>T

1 paper

NM_001382508.1

p.P147S

c.439C>T

1 paper

NM_001382508.1

p.P121insFs

c.362_363insT

1 paper

NM_001382508.1

p.P149delins

c.445_446delinsTT