Varaico: Literature-Extracted Genetic Variants

DROSHA

357 papers

RefSeq Summary

This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA...

Pfam Domains

Helical_CED_Droshaaa 718–850UCSCRibonuclease 3, central domain, two antiparallel helical region

Ribonucleas_3_3aa 957–1072UCSCRibonuclease-III-like

Ribonuclease_3aa 1144–1233UCSCRibonuclease III domain

dsrmaa 1261–1332UCSCDouble-stranded RNA binding motif

Gene Aliases

HGNC Name

drosha ribonuclease III

HGNC Previous Symbol

RNASEN

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

5 papers

NM_001382508.1

p.P32L

c.95C>T

Surrounding Variants

1 paper

NM_001382508.1

p.P32S

c.94C>T

1 paper

NM_001382508.1

p.S33F

c.98C>T

1 paper

NM_001382508.1

p.S33C

c.98C>G

1 paper

NM_001382508.1

p.P36L

c.107C>T

1 paper

NM_001382508.1

p.A27G

c.80C>G

1 paper

NM_001382508.1

p.Q37P

c.110A>C

1 paper

NM_001382508.1

p.G24E

c.71G>A

1 paper

NM_001382508.1

p.G23_G24insFs

c.69_70insG

1 paper

NM_001382508.1

p.L42V

c.124C>G

2 papers

NM_001382508.1

p.R22*

c.64C>T

1 paper

NM_001382508.1

p.P44P

c.132T>G

1 paper

NM_001382508.1

p.P19P

c.57C>T