Varaico: Literature-Extracted Genetic Variants

Gene:DUSP1
Variant:p.A250D

DUSP1

98 papers

RefSeq Summary

The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in s...

Pfam Domains

Rhodaneseaa 9–131UCSCRhodanese-like domain
DSPcaa 181–311UCSCDual specificity phosphatase, catalytic domain

Gene Aliases

HGNC Name

dual specificity phosphatase 1

HGNC Previous Symbol

PTPN10

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_004417.4
p.A250D
c.749C>A
Surrounding Variants
4 papers
NM_004417.4
p.C258S
c.772T>A
4 papers
NM_004417.4
p.C258S
c.773G>C
1 paper
NM_004417.4
p.L270R
c.809T>G
1 paper
NM_004417.4
p.R278*
c.832C>T
1 paper
NM_004417.4
p.S310S
c.930C>A
1 paper
NM_004417.4
p.P315P
c.945G>A
1 paper
NM_004417.4
p.E320V
c.959A>T
3 papers
NM_004417.4
p.A325T
c.973G>A
1 paper
NM_004417.4
p.D330N
c.988G>A
1 paper
NM_004417.4
p.T333A
c.997A>G
1 paper
NM_004417.4
p.V338M
c.1012G>A
1 paper
NM_004417.4
p.F341L
c.1021T>C
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."