Varaico: Literature-Extracted Genetic Variants

Gene:DUSP1
Variant:p.K221R

DUSP1

98 papers

RefSeq Summary

The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in s...

Pfam Domains

Rhodaneseaa 9–131UCSCRhodanese-like domain
DSPcaa 181–311UCSCDual specificity phosphatase, catalytic domain

Gene Aliases

HGNC Name

dual specificity phosphatase 1

HGNC Previous Symbol

PTPN10

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_004417.4
p.K221R
c.662A>G
Surrounding Variants
1 paper
NM_004417.4
p.D227N
c.679G>A
1 paper
NM_004417.4
p.V206I
c.616G>A
1 paper
NM_004417.4
p.I200I
c.600C>A
5 papers
NM_004417.4
p.Y187H
c.559T>C
1 paper
NM_004417.4
p.P174S
c.520C>T
1 paper
NM_004417.4
p.Q171_G172Splc
c.513+167A>G
1 paper
NM_004417.4
p.Q171_G172Splc
c.513+125A>G
1 paper
NM_004417.4
p.A250D
c.749C>A
4 papers
NM_004417.4
p.C258S
c.772T>A
4 papers
NM_004417.4
p.C258S
c.773G>C
1 paper
NM_004417.4
p.L270R
c.809T>G
1 paper
NM_004417.4
p.L147I
c.439C>A
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