Varaico: Literature-Extracted Genetic Variants

Gene:EGLN1
Variant:p.K255E

EGLN1

309 papers

RefSeq Summary

The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central ...

Pfam Domains

zf-MYNDaa 21–58UCSCMYND finger
2OG-FeII_Oxy_3aa 298–391UCSC2OG-Fe(II) oxygenase superfamily

Gene Aliases

HGNC Name

egl-9 family hypoxia inducible factor 1

HGNC Alias Symbols

SM-20; PHD2; ZMYND6; HIFPH2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
2 papers
NM_022051.3
p.K255E
c.763A>G
Surrounding Variants
1 paper
NM_022051.3
p.K255N
c.765G>T
1 paper
NM_022051.3
p.K255N
c.765G>C
8 papers
NM_022051.3
p.D254H
c.760G>C
1 paper
NM_022051.3
p.V241_K255del15
c.721_764del45
1 paper
NM_022051.3
p.T257I
c.770C>T
1 paper
NM_022051.3
p.W258R
c.772T>C
1 paper
NM_022051.3
p.W258R
c.772T>A
1 paper
NM_022051.3
p.I251I
c.753C>T
1 paper
NM_022051.3
p.I251L
c.751A>C
1 paper
NM_022051.3
p.D250Y
c.748G>T
1 paper
NM_022051.3
p.E260G
c.779A>G
1 paper
NM_022051.3
p.K262E
c.784A>G
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