Varaico: Literature-Extracted Genetic Variants

EIF2AK2

344 papers

RefSeq Summary

The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate trans...

Pfam Domains

dsrmaa 10–75UCSCDouble-stranded RNA binding motif

dsrmaa 101–165UCSCDouble-stranded RNA binding motif

Pkinaseaa 267–537UCSCProtein kinase domain

Gene Aliases

HGNC Name

eukaryotic translation initiation factor 2 alpha kinase 2

HGNC Previous Symbol

PRKR

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_001135651.3

p.Y323F

c.968A>T

Surrounding Variants

1 paper

NM_001135651.3

p.Y323D

c.967T>G

2 papers

NM_001135651.3

p.G325S

c.973G>A

1 paper

NM_001135651.3

p.G325A

c.974G>C

1 paper

NM_001135651.3

p.I320delFs

c.958delT

1 paper

NM_001135651.3

p.C326W

c.978T>G

1 paper

NM_001135651.3

p.W327G

c.979T>G

1 paper

NM_001135651.3

p.W327L

c.980G>T

1 paper

NM_001135651.3

p.W327S

c.980G>C

1 paper

NM_001135651.3

p.D328A

c.983A>C

1 paper

NM_001135651.3

p.G329V

c.986G>T

1 paper

NM_001135651.3

p.D316delFs

c.948delA

1 paper

NM_001135651.3

p.L315_D316del1

c.945_947delTCA