Varaico: Literature-Extracted Genetic Variants

EIF2AK2

344 papers

RefSeq Summary

The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate trans...

Pfam Domains

dsrmaa 10–75UCSCDouble-stranded RNA binding motif

dsrmaa 101–165UCSCDouble-stranded RNA binding motif

Pkinaseaa 267–537UCSCProtein kinase domain

Gene Aliases

HGNC Name

eukaryotic translation initiation factor 2 alpha kinase 2

HGNC Previous Symbol

PRKR

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001135651.3

p.S203S

c.609A>G

Surrounding Variants

1 paper

NM_001135651.3

p.E205G

c.614A>G

1 paper

NM_001135651.3

p.S209L

c.626C>T

1 paper

NM_001135651.3

p.L198Splc

c.594-2A>T

1 paper

NM_001135651.3

p.S213A

c.637T>G

1 paper

NM_001135651.3

p.F208_I215del0

c.624_644del21

1 paper

NM_001135651.3

p.N216D

c.646A>G

1 paper

NM_001135651.3

p.S226L

c.677C>T

1 paper

NM_001135651.3

p.S226*

c.677C>A

1 paper

NM_001135651.3

p.M229_N230Splc

c.687+2T>C

1 paper

NM_001135651.3

p.L198I

c.592C>A

1 paper

NM_001135651.3

p.V194delFs

c.582delC

1 paper

NM_001135651.3

p.S192C

c.575C>G