Varaico: Literature-Extracted Genetic Variants

EIF2AK2

344 papers

RefSeq Summary

The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate trans...

Pfam Domains

dsrmaa 10–75UCSCDouble-stranded RNA binding motif

dsrmaa 101–165UCSCDouble-stranded RNA binding motif

Pkinaseaa 267–537UCSCProtein kinase domain

Gene Aliases

HGNC Name

eukaryotic translation initiation factor 2 alpha kinase 2

HGNC Previous Symbol

PRKR

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001135651.3

p.L198I

c.592C>A

Surrounding Variants

1 paper

NM_001135651.3

p.V194delFs

c.582delC

1 paper

NM_001135651.3

p.S192C

c.575C>G

1 paper

NM_001135651.3

p.E187D

c.561G>T

1 paper

NM_001135651.3

p.E187D

c.561G>C

1 paper

NM_001135651.3

p.E187Q

c.559G>C

2 papers

NM_001135651.3

p.T185M

c.554C>T

1 paper

NM_001135651.3

p.T184N

c.551C>A

1 paper

NM_001135651.3

p.Y176Y

c.528C>T

1 paper

NM_001135651.3

p.Y176H

c.526T>C

1 paper

NM_001135651.3

p.D175Y

c.523G>T

1 paper

NM_001135651.3

p.V172_K173Splc

c.517-50A>G

1 paper

NM_001135651.3

p.L198Splc

c.594-2A>T