Varaico: Literature-Extracted Genetic Variants

EIF2AK2

344 papers

RefSeq Summary

The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate trans...

Pfam Domains

dsrmaa 10–75UCSCDouble-stranded RNA binding motif

dsrmaa 101–165UCSCDouble-stranded RNA binding motif

Pkinaseaa 267–537UCSCProtein kinase domain

Gene Aliases

HGNC Name

eukaryotic translation initiation factor 2 alpha kinase 2

HGNC Previous Symbol

PRKR

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001135651.3

p.G147delFs

c.440_441delAC

Surrounding Variants

1 paper

NM_001135651.3

p.G147V

c.440G>T

1 paper

NM_001135651.3

p.Y142C

c.425A>G

1 paper

NM_001135651.3

p.A157T

c.469G>A

3 papers

NM_001135651.3

p.G138A

c.413G>C

1 paper

NM_001135651.3

p.A158S

c.472G>T

1 paper

NM_001135651.3

p.A158D

c.473C>A

1 paper

NM_001135651.3

p.A158delFs

c.473delG

1 paper

NM_001135651.3

p.C135_K136ins2

c.405_406ins6

1 paper

NM_001135651.3

p.K134delFs

c.400delT

1 paper

NM_001135651.3

p.A161S

c.481G>T

1 paper

NM_001135651.3

p.A161T

c.481G>A

1 paper

NM_001135651.3

p.Y162H

c.484T>C