Varaico: Literature-Extracted Genetic Variants

EIF2AK2

344 papers

RefSeq Summary

The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate trans...

Pfam Domains

dsrmaa 10–75UCSCDouble-stranded RNA binding motif

dsrmaa 101–165UCSCDouble-stranded RNA binding motif

Pkinaseaa 267–537UCSCProtein kinase domain

Gene Aliases

HGNC Name

eukaryotic translation initiation factor 2 alpha kinase 2

HGNC Previous Symbol

PRKR

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001135651.3

p.A109_K111del3

c.325_332del9

Surrounding Variants

3 papers

NM_001135651.3

p.A109V

c.326C>T

6 papers

NM_001135651.3

p.A109S

c.325G>T

1 paper

NM_001135651.3

p.G103D

c.308G>A

1 paper

NM_001135651.3

p.G103C

c.307G>T

1 paper

NM_001135651.3

p.A122T

c.364G>A

1 paper

NM_001135651.3

p.M98I

c.294G>A

5 papers

NM_001135651.3

p.S97F

c.290C>T

1 paper

NM_001135651.3

p.S97Y

c.290C>A

1 paper

NM_001135651.3

p.S97A

c.289T>G

1 paper

NM_001135651.3

p.G95delFs

c.284delC

1 paper

NM_001135651.3

p.G95E

c.284G>A

1 paper

NM_001135651.3

p.G130R

c.388G>C