Varaico: Literature-Extracted Genetic Variants

EIF2AK2

344 papers

RefSeq Summary

The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate trans...

Pfam Domains

dsrmaa 10–75UCSCDouble-stranded RNA binding motif

dsrmaa 101–165UCSCDouble-stranded RNA binding motif

Pkinaseaa 267–537UCSCProtein kinase domain

Gene Aliases

HGNC Name

eukaryotic translation initiation factor 2 alpha kinase 2

HGNC Previous Symbol

PRKR

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001135651.3

p.E54V

c.161A>T

Surrounding Variants

1 paper

NM_001135651.3

p.D48_P53del0

c.142_159del18

1 paper

NM_001135651.3

p.P53R

c.158C>G

1 paper

NM_001135651.3

p.E51V

c.152A>T

1 paper

NM_001135651.3

p.R58T

c.173G>C

1 paper

NM_001135651.3

p.Q44delFs

c.131_132delTT

6 papers

NM_001135651.3

p.K64E

c.190A>G

1 paper

NM_001135651.3

p.A67E

c.200C>A

1 paper

NM_001135651.3

p.A68D

c.203C>A

1 paper

NM_001135651.3

p.R40W

c.118A>T

1 paper

NM_001135651.3

p.K69E

c.205A>G

1 paper

NM_001135651.3

p.D38Y

c.112G>T

1 paper

NM_001135651.3

p.H37del1

c.109_111delATG