Varaico: Literature-Extracted Genetic Variants

EIF2AK2

344 papers

RefSeq Summary

The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate trans...

Pfam Domains

dsrmaa 10–75UCSCDouble-stranded RNA binding motif

dsrmaa 101–165UCSCDouble-stranded RNA binding motif

Pkinaseaa 267–537UCSCProtein kinase domain

Gene Aliases

HGNC Name

eukaryotic translation initiation factor 2 alpha kinase 2

HGNC Previous Symbol

PRKR

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_001135651.3

p.N32S

c.95A>G

Surrounding Variants

3 papers

NM_001135651.3

p.N32T

c.95A>C

1 paper

NM_001135651.3

p.S33T

c.97T>A

3 papers

NM_001135651.3

p.P31R

c.92C>G

2 papers

NM_001135651.3

p.P31S

c.91C>T

1 paper

NM_001135651.3

p.G34R

c.100G>C

1 paper

NM_001135651.3

p.G34R

c.100G>A

1 paper

NM_001135651.3

p.P35S

c.103C>T

1 paper

NM_001135651.3

p.P35delFs

c.103delG

1 paper

NM_001135651.3

p.Q28*

c.82C>T

1 paper

NM_001135651.3

p.D38Y

c.112G>T

1 paper

NM_001135651.3

p.H37del1

c.109_111delATG

1 paper

NM_001135651.3

p.Q21*

c.61C>T