Varaico: Literature-Extracted Genetic Variants

EIF2AK2

344 papers

RefSeq Summary

The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate trans...

Pfam Domains

dsrmaa 10–75UCSCDouble-stranded RNA binding motif

dsrmaa 101–165UCSCDouble-stranded RNA binding motif

Pkinaseaa 267–537UCSCProtein kinase domain

Gene Aliases

HGNC Name

eukaryotic translation initiation factor 2 alpha kinase 2

HGNC Previous Symbol

PRKR

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001135651.3

p.Y17C

c.50A>G

Surrounding Variants

1 paper

NM_001135651.3

p.Y17*

c.51C>A

1 paper

NM_001135651.3

p.R18G

c.52C>G

1 paper

NM_001135651.3

p.Q19*

c.55C>T

1 paper

NM_001135651.3

p.Q19L

c.56A>T

1 paper

NM_001135651.3

p.N15I

c.44A>T

1 paper

NM_001135651.3

p.L14H

c.41T>A

1 paper

NM_001135651.3

p.K20R

c.59A>G

1 paper

NM_001135651.3

p.Q21*

c.61C>T

1 paper

NM_001135651.3

p.E12insFs

c.34_35insC

5 papers

NM_001135651.3

p.M11L

c.31A>T

2 papers

NM_001135651.3

p.M11V

c.31A>G

6 papers

NM_001135651.3

p.M11L

c.31A>C