Varaico: Literature-Extracted Genetic Variants

EIF2AK2

344 papers

RefSeq Summary

The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate trans...

Pfam Domains

dsrmaa 10–75UCSCDouble-stranded RNA binding motif

dsrmaa 101–165UCSCDouble-stranded RNA binding motif

Pkinaseaa 267–537UCSCProtein kinase domain

Gene Aliases

HGNC Name

eukaryotic translation initiation factor 2 alpha kinase 2

HGNC Previous Symbol

PRKR

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

6 papers

NM_001135651.3

p.M11L

c.31A>C

Surrounding Variants

5 papers

NM_001135651.3

p.M11L

c.31A>T

2 papers

NM_001135651.3

p.M11V

c.31A>G

1 paper

NM_001135651.3

p.F10L

c.30C>G

1 paper

NM_001135651.3

p.F10L

c.30C>A

1 paper

NM_001135651.3

p.F10V

c.28T>G

1 paper

NM_001135651.3

p.F10L

c.28T>C

1 paper

NM_001135651.3

p.E12insFs

c.34_35insC

1 paper

NM_001135651.3

p.L14H

c.41T>A

1 paper

NM_001135651.3

p.N15I

c.44A>T

1 paper

NM_001135651.3

p.Y17C

c.50A>G

1 paper

NM_001135651.3

p.Y17*

c.51C>A

2 papers

NM_001135651.3

p.D4Y

c.10G>T