Varaico: Literature-Extracted Genetic Variants

Gene:EIF2AK3
Variant:p.V882L

EIF2AK3

596 papers

RefSeq Summary

The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation ...

Pfam Domains

Pkinaseaa 593–676UCSCProtein kinase domain
Pkinaseaa 864–1077UCSCProtein kinase domain

Gene Aliases

HGNC Name

eukaryotic translation initiation factor 2 alpha kinase 3

HGNC Alias Symbols

PEK; PERK

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_004836.7
p.V882L
c.2644G>T
Surrounding Variants
1 paper
NM_004836.7
p.V882L
c.2644G>C
1 paper
NM_004836.7
p.K881K
c.2643G>A
1 paper
NM_004836.7
p.Y883C
c.2648A>G
1 paper
NM_004836.7
p.S879P
c.2635T>C
1 paper
NM_004836.7
p.S878T
c.2633G>C
1 paper
NM_004836.7
p.Q887Q
c.2661A>G
1 paper
NM_004836.7
p.Q876_P877ins10
c.2626_2630ins30
1 paper
NM_004836.7
p.L875L
c.2625C>T
1 paper
NM_004836.7
p.L875R
c.2624T>G
1 paper
NM_004836.7
p.M888I
c.2664G>T
1 paper
NM_004836.7
p.M888I
c.2664G>C
1 paper
NM_004836.7
p.M888I
c.2664G>A
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."