Varaico: Literature-Extracted Genetic Variants

Gene:EIF2AK3
Variant:p.T871T

EIF2AK3

596 papers

RefSeq Summary

The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation ...

Pfam Domains

Pkinaseaa 593–676UCSCProtein kinase domain
Pkinaseaa 864–1077UCSCProtein kinase domain

Gene Aliases

HGNC Name

eukaryotic translation initiation factor 2 alpha kinase 3

HGNC Alias Symbols

PEK; PERK

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_004836.7
p.T871T
c.2613C>A
Surrounding Variants
1 paper
NM_004836.7
p.T871N
c.2612C>A
2 papers
NM_004836.7
p.K869_N870del2
c.2605_2609del6
1 paper
NM_004836.7
p.N870insFs
c.2609dupA
1 paper
NM_004836.7
p.N870T
c.2609A>C
2 papers
NM_004836.7
p.T872_E873delFs
c.2614_2617del4
1 paper
NM_004836.7
p.L875R
c.2624T>G
1 paper
NM_004836.7
p.L875L
c.2625C>T
1 paper
NM_004836.7
p.Q876_P877ins10
c.2626_2630ins30
2 papers
NM_004836.7
p.L863_L865delFs
c.2589_2593del5
1 paper
NM_004836.7
p.S878T
c.2633G>C
1 paper
NM_004836.7
p.S879P
c.2635T>C
2 papers
NM_004836.7
p.L863fs
c.2587_2588fs
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."