Varaico: Literature-Extracted Genetic Variants

Gene:EIF2AK3
Variant:p.A535T

EIF2AK3

596 papers

RefSeq Summary

The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation ...

Pfam Domains

Pkinaseaa 593–676UCSCProtein kinase domain
Pkinaseaa 864–1077UCSCProtein kinase domain

Gene Aliases

HGNC Name

eukaryotic translation initiation factor 2 alpha kinase 3

HGNC Alias Symbols

PEK; PERK

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
2 papers
NM_004836.7
p.A535T
c.1603G>A
Surrounding Variants
1 paper
NM_004836.7
p.I534M
c.1602A>G
1 paper
NM_004836.7
p.I534T
c.1601T>C
1 paper
NM_004836.7
p.T536T
c.1608A>G
5 papers
NM_004836.7
p.C532*
c.1596T>A
2 papers
NM_004836.7
p.T537M
c.1610C>T
1 paper
NM_004836.7
p.T537K
c.1610C>A
1 paper
NM_004836.7
p.T537T
c.1611G>A
1 paper
NM_004836.7
p.T536_T537del1
c.1608_1610delGTT
1 paper
NM_004836.7
p.T537del1
c.1609_1610delCGT
1 paper
NM_004836.7
p.F531L
c.1593T>G
1 paper
NM_004836.7
p.F531F
c.1593T>C
1 paper
NM_004836.7
p.F531L
c.1593T>A
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