Varaico: Literature-Extracted Genetic Variants

Gene:EIF2AK3
Variant:p.S409A

EIF2AK3

596 papers

RefSeq Summary

The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation ...

Pfam Domains

Pkinaseaa 593–676UCSCProtein kinase domain
Pkinaseaa 864–1077UCSCProtein kinase domain

Gene Aliases

HGNC Name

eukaryotic translation initiation factor 2 alpha kinase 3

HGNC Alias Symbols

PEK; PERK

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_004836.7
p.S409A
c.1225T>G
Surrounding Variants
1 paper
NM_004836.7
p.S410G
c.1228A>G
1 paper
NM_004836.7
p.F407L
c.1221T>G
1 paper
NM_004836.7
p.F407L
c.1221T>A
1 paper
NM_004836.7
p.F407L
c.1219T>C
1 paper
NM_004836.7
p.P411T
c.1231C>A
1 paper
NM_004836.7
p.K406K
c.1218G>A
1 paper
NM_004836.7
p.P411P
c.1233C>T
1 paper
NM_004836.7
p.K412K
c.1236G>A
1 paper
NM_004836.7
p.I403S
c.1208T>G
1 paper
NM_004836.7
p.I403T
c.1208T>C
1 paper
NM_004836.7
p.E415A
c.1244A>C
1 paper
NM_004836.7
p.V401V
c.1203C>T
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