Varaico: Literature-Extracted Genetic Variants

ERBB3

1,503 papers

RefSeq Summary

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase doma...

Pfam Domains

Recep_L_domainaa 55–167UCSCReceptor L domain

Furin-likeaa 170–332UCSCFurin-like cysteine rich region

Recep_L_domainaa 353–474UCSCReceptor L domain

GF_recep_IVaa 499–630UCSCGrowth factor receptor domain IV

PK_Tyr_Ser-Thraa 709–965UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

erb-b2 receptor tyrosine kinase 3

HGNC Previous Symbol

LCCS2

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001982.4

p.M905L

c.2713A>C

Surrounding Variants

1 paper

NM_001982.4

p.M905L

c.2713A>T

1 paper

NM_001982.4

p.L904F

c.2712G>C

1 paper

NM_001982.4

p.L904F

c.2712G>T

1 paper

NM_001982.4

p.M905I

c.2715G>A

1 paper

NM_001982.4

p.M905I

c.2715G>C

1 paper

NM_001982.4

p.M905I

c.2715G>T

1 paper

NM_001982.4

p.T906P

c.2716A>C

1 paper

NM_001982.4

p.T906A

c.2716A>G

4 papers

NM_001982.4

p.T906S

c.2716A>T

1 paper

NM_001982.4

p.T906N

c.2717C>A

4 papers

NM_001982.4

p.T906S

c.2717C>G

1 paper

NM_001982.4

p.E903D

c.2709G>C