ERCC excision repair 6 like, spindle assembly checkpoint helicase

FLJ20105

PICH

RAD26L

excision repair cross-complementing rodent repair deficiency, complementation group 6-like

excision repair cross-complementation group 6 like

PLK1-interacting checkpoint helicase

DNA excision repair protein ERCC-6-like

ATP-dependent helicase ERCC6-like

Tumor antigen BJ-HCC-15

This gene encodes a member of the SWItch/Sucrose Non-Fermentable (SWI/SNF2) family of proteins, and contains a SNF2-like ATPase domain and a PICH family domain. One distinguishing feature of this SWI/SNF protein family member is that during interphase, the protein is excluded from the nucleus, and only associates with chromatin after the nuclear envelope has broken down. This protein is a DNA translocase that is thought to bind double-stranded DNA that is exposed to stretching forces, such as those exerted by the mitotic spindle. This protein associates with ribosomal DNA and ultra-fine DNA bridges (UFBs), fine structures that connect sister chromatids during anaphase at some sites such as fragile sites, telomeres and centromeres. This gene is required for the faithful segregation of sister chromatids during mitosis, and the ATPase activity of this protein required for the resolution of UFBs before cytokinesis. [provided by RefSeq, May 2017].

Varaico: Literature-Extracted Genetic Variants

ERCC6L

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Alias Symbols