Varaico: Literature-Extracted Genetic Variants

FBXW4

30 papers

RefSeq Summary

This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly ...

Pfam Domains

F-box-likeaa 28–74UCSCF-box-like

F-box-likeaa 183–229UCSCF-box-like

WD40aa 192–228UCSCWD domain, G-beta repeat

WD40aa 326–365UCSCWD domain, G-beta repeat

WD40aa 347–383UCSCWD domain, G-beta repeat

WD40aa 481–520UCSCWD domain, G-beta repeat

Gene Aliases

HGNC Name

F-box and WD repeat domain containing 4

HGNC Previous Symbol

SHFM3

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_022039.4

p.C526W

c.1578C>G

Surrounding Variants

1 paper

NM_022039.4

p.C526G

c.1576T>G

1 paper

NM_022039.4

p.L518V

c.1552C>G

2 papers

NM_022039.4

p.N503_L505del3

c.1507_1514del9

1 paper

NM_022039.4

p.S434Splc

c.1301+4493T>C