Varaico: Literature-Extracted Genetic Variants

FBXW4

30 papers

RefSeq Summary

This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly ...

Pfam Domains

F-box-likeaa 28–74UCSCF-box-like

F-box-likeaa 183–229UCSCF-box-like

WD40aa 192–228UCSCWD domain, G-beta repeat

WD40aa 326–365UCSCWD domain, G-beta repeat

WD40aa 347–383UCSCWD domain, G-beta repeat

WD40aa 481–520UCSCWD domain, G-beta repeat

Gene Aliases

HGNC Name

F-box and WD repeat domain containing 4

HGNC Previous Symbol

SHFM3

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_022039.4

p.R308C

c.922C>T

Surrounding Variants

1 paper

NM_022039.4

p.P301L

c.902C>T

1 paper

NM_022039.4

p.H343Y

c.1027C>T

1 paper

NM_022039.4

p.C273Y

c.818G>A

2 papers

NM_022039.4

p.K380_V381Splc

c.1141-2A>C

1 paper

NM_022039.4

p.A406T

c.1216G>A