Varaico: Literature-Extracted Genetic Variants

FGA

277 papers

RefSeq Summary

This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by t...

Pfam Domains

Fib_alphaaa 49–191UCSCFibrinogen alpha/beta chain family

Fibrinogen_aCaa 445–509UCSCFibrinogen alpha C domain

Fibrinogen_Caa 628–863UCSCFibrinogen beta and gamma chains, C-terminal globular domain

Gene Aliases

HGNC Name

fibrinogen alpha chain

HGNC Previous Name

fibrinogen, A alpha polypeptide

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_021871.4

p.L637F

c.1911G>T

Surrounding Variants

1 paper

NM_021871.4

p.K639E

c.1915A>G

1 paper

NM_021871.4

p.S635S

c.1905T>G

1 paper

NM_021871.4

p.H633D

c.1897C>G

1 paper

NM_021871.4

p.G631G

c.1893T>A

1 paper

NM_021871.4

p.G631D

c.1892G>A

1 paper

NM_021871.4

p.P644A

c.1930C>G

2 papers

NM_021871.4

p.R627L

c.1880G>T

1 paper

NM_021871.4

p.R627P

c.1880G>C

1 paper

NM_021871.4

p.T619A

c.1855A>G

5 papers

NM_021871.4

p.T616delFs

c.1846delT

1 paper

NM_021871.4

p.E614K

c.1840G>A

1 paper

NM_021871.4

p.H613N

c.1837C>A