Varaico: Literature-Extracted Genetic Variants

FGA

277 papers

RefSeq Summary

This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by t...

Pfam Domains

Fib_alphaaa 49–191UCSCFibrinogen alpha/beta chain family

Fibrinogen_aCaa 445–509UCSCFibrinogen alpha C domain

Fibrinogen_Caa 628–863UCSCFibrinogen beta and gamma chains, C-terminal globular domain

Gene Aliases

HGNC Name

fibrinogen alpha chain

HGNC Previous Name

fibrinogen, A alpha polypeptide

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_021871.4

p.T584I

c.1751C>T

Surrounding Variants

2 papers

NM_021871.4

p.S585insFs

c.1754_1755insT

2 papers

NM_021871.4

p.S585_S586insFs

c.1755_1756insT

1 paper

NM_021871.4

p.F583_S586del4

c.1747_1757del12

1 paper

NM_021871.4

p.T587M

c.1760C>T

1 paper

NM_021871.4

p.S580I

c.1739G>T

1 paper

NM_021871.4

p.Y579Fs

c.1736_1737delinsTTGGAATTTTFs

1 paper

NM_021871.4

p.Y579F

c.1736A>T

1 paper

NM_021871.4

p.Y589*

c.1767C>G

1 paper

NM_021871.4

p.Y589*

c.1767C>A

1 paper

NM_021871.4

p.S578G

c.1732A>G

1 paper

NM_021871.4

p.R591fs

c.1771_1772fs

1 paper

NM_021871.4

p.R591delFs

c.1771delT