Varaico: Literature-Extracted Genetic Variants

FGA

277 papers

RefSeq Summary

This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by t...

Pfam Domains

Fib_alphaaa 49–191UCSCFibrinogen alpha/beta chain family

Fibrinogen_aCaa 445–509UCSCFibrinogen alpha C domain

Fibrinogen_Caa 628–863UCSCFibrinogen beta and gamma chains, C-terminal globular domain

Gene Aliases

HGNC Name

fibrinogen alpha chain

HGNC Previous Name

fibrinogen, A alpha polypeptide

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

5 papers

NM_021871.4

p.R547delFs

c.1639delT

Surrounding Variants

1 paper

NM_021871.4

p.M536_S546del11

c.1606_1637del33

1 paper

NM_021871.4

p.R547S

c.1641G>C

2 papers

NM_021871.4

p.R547fs

c.1639_1640fs

1 paper

NM_021871.4

p.G548D

c.1643G>A

16 papers

NM_021871.4

p.E545V

c.1634A>T

7 papers

NM_021871.4

p.E545K

c.1633G>A

7 papers

NM_021871.4

p.T544delFs

c.1632delA

1 paper

NM_021871.4

p.E550K

c.1648G>A

1 paper

NM_021871.4

p.E550insFs

c.1649_1650insCA

1 paper

NM_021871.4

p.T544fs

c.1630_1631fs

1 paper

NM_021871.4

p.E550_S551insFs

c.1650_1651insCA

7 papers

NM_021871.4

p.E543delFs

c.1629delC