Varaico: Literature-Extracted Genetic Variants

FGA

277 papers

RefSeq Summary

This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by t...

Pfam Domains

Fib_alphaaa 49–191UCSCFibrinogen alpha/beta chain family

Fibrinogen_aCaa 445–509UCSCFibrinogen alpha C domain

Fibrinogen_Caa 628–863UCSCFibrinogen beta and gamma chains, C-terminal globular domain

Gene Aliases

HGNC Name

fibrinogen alpha chain

HGNC Previous Name

fibrinogen, A alpha polypeptide

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

6 papers

NM_021871.4

p.L537delFs

c.1611delT

Surrounding Variants

2 papers

NM_021871.4

p.G538fs

c.1612_1613fs

2 papers

NM_021871.4

p.G538E

c.1613G>A

4 papers

NM_021871.4

p.F540fs

c.1618_1619fs

1 paper

NM_021871.4

p.M536_L537insC

c.1606_1610ins3

2 papers

NM_021871.4

p.F540insFs

c.1619_1620insCA

1 paper

NM_021871.4

p.F540S

c.1619T>C

2 papers

NM_021871.4

p.M536_F540Fs

c.1606_1620delinsCAFs

1 paper

NM_021871.4

p.V541I

c.1621G>A

6 papers

NM_021871.4

p.F540delFs

c.1620delA

3 papers

NM_021871.4

p.M536_F540del0

c.1606_1620del15

1 paper

NM_021871.4

p.P535T

c.1603C>A

3 papers

NM_021871.4

p.V541fs

c.1621_1622fs