Varaico: Literature-Extracted Genetic Variants

FGA

277 papers

RefSeq Summary

This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by t...

Pfam Domains

Fib_alphaaa 49–191UCSCFibrinogen alpha/beta chain family

Fibrinogen_aCaa 445–509UCSCFibrinogen alpha C domain

Fibrinogen_Caa 628–863UCSCFibrinogen beta and gamma chains, C-terminal globular domain

Gene Aliases

HGNC Name

fibrinogen alpha chain

HGNC Previous Name

fibrinogen, A alpha polypeptide

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_021871.4

p.E441K

c.1321G>A

Surrounding Variants

1 paper

NM_021871.4

p.L442F

c.1324C>T

1 paper

NM_021871.4

p.K446E

c.1336A>G

1 paper

NM_021871.4

p.K446R

c.1337A>G

1 paper

NM_021871.4

p.T435N

c.1304C>A

1 paper

NM_021871.4

p.V434I

c.1300G>A

1 paper

NM_021871.4

p.K432I

c.1295A>T

1 paper

NM_021871.4

p.H429Q

c.1287C>G

1 paper

NM_021871.4

p.S453N

c.1358G>A

1 paper

NM_021871.4

p.T454A

c.1360A>G

1 paper

NM_021871.4

p.E427E

c.1281G>A

2 papers

NM_021871.4

p.T456A

c.1366A>G

1 paper

NM_021871.4

p.T457fs

c.1369_1370fs