Varaico: Literature-Extracted Genetic Variants

FGA

277 papers

RefSeq Summary

This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by t...

Pfam Domains

Fib_alphaaa 49–191UCSCFibrinogen alpha/beta chain family

Fibrinogen_aCaa 445–509UCSCFibrinogen alpha C domain

Fibrinogen_Caa 628–863UCSCFibrinogen beta and gamma chains, C-terminal globular domain

Gene Aliases

HGNC Name

fibrinogen alpha chain

HGNC Previous Name

fibrinogen, A alpha polypeptide

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_021871.4

p.D409G

c.1226A>G

Surrounding Variants

1 paper

NM_021871.4

p.N407S

c.1220A>G

2 papers

NM_021871.4

p.G411G

c.1233C>A

1 paper

NM_021871.4

p.N407H

c.1219A>C

1 paper

NM_021871.4

p.P405_N406insFs

c.1215_1218dup4

1 paper

NM_021871.4

p.T412S

c.1234A>T

3 papers

NM_021871.4

p.P405delFs

c.1215delA

1 paper

NM_021871.4

p.P405T

c.1213C>A

1 paper

NM_021871.4

p.E414K

c.1240G>A

1 paper

NM_021871.4

p.R404K

c.1211G>A

1 paper

NM_021871.4

p.R404G

c.1210A>G

1 paper

NM_021871.4

p.R404R

c.1210A>C

2 papers

NM_021871.4

p.E415*

c.1243G>T