Varaico: Literature-Extracted Genetic Variants

FLT3

2,401 papers

RefSeq Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, whic...

Pfam Domains

igaa 258–343UCSCImmunoglobulin domain

PK_Tyr_Ser-Thraa 610–943UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 3

HGNC Alias Symbols

FLK2; CD135

Papers

RefSeq ID

Protein change

DNA change

1–12 of 2382 variants

630 papers

NM_004119.3

p.D835Y

c.2503G>T

280 papers

NM_004119.3

p.D835H

c.2503G>C

244 papers

NM_004119.3

p.D835V

c.2504A>T

178 papers

NM_004119.3

p.F691L

c.2073T>G

177 papers

NM_004119.3

p.F691L

c.2071T>C

177 papers

NM_004119.3

p.F691L

c.2073T>A

176 papers

NM_004119.3

p.D835E

c.2505T>G

175 papers

NM_004119.3

p.D835E

c.2505T>A

143 papers

NM_004119.3

p.N676K

c.2028C>A

142 papers

NM_004119.3

p.N676K

c.2028C>G

105 papers

NM_004119.3

p.Y842C

c.2525A>G

88 papers

NM_004119.3

p.I836_M837del1

c.2508_2510delATG