Varaico: Literature-Extracted Genetic Variants

FLT3

2,401 papers

RefSeq Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, whic...

Pfam Domains

igaa 258–343UCSCImmunoglobulin domain

PK_Tyr_Ser-Thraa 610–943UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 3

HGNC Alias Symbols

FLK2; CD135

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

10 papers

NM_004119.3

p.M837K

c.2510T>A

Surrounding Variants

2 papers

NM_004119.3

p.M837T

c.2510T>C

2 papers

NM_004119.3

p.M837I

c.2511G>T

2 papers

NM_004119.3

p.M837I

c.2511G>C

2 papers

NM_004119.3

p.M837I

c.2511G>A

88 papers

NM_004119.3

p.I836_M837del1

c.2508_2510delATG

1 paper

NM_004119.3

p.M837L

c.2509A>T

1 paper

NM_004119.3

p.M837L

c.2509A>C

1 paper

NM_004119.3

p.D835_M837delins

c.2505_2509delinsCC

1 paper

NM_004119.3

p.I836I

c.2508C>T

31 papers

NM_004119.3

p.I836M

c.2508C>G

1 paper

NM_004119.3

p.I836insFs

c.2507dupT

1 paper

NM_004119.3

p.I836fs

c.2506_2507fs