Varaico: Literature-Extracted Genetic Variants

FLT3

2,401 papers

RefSeq Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, whic...

Pfam Domains

igaa 258–343UCSCImmunoglobulin domain

PK_Tyr_Ser-Thraa 610–943UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 3

HGNC Alias Symbols

FLK2; CD135

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

244 papers

NM_004119.3

p.D835V

c.2504A>T

Surrounding Variants

18 papers

NM_004119.3

p.D835G

c.2504A>G

51 papers

NM_004119.3

p.D835A

c.2504A>C

1 paper

NM_004119.3

p.R834_D835ins1

c.2502_2503insAGT

1 paper

NM_004119.3

p.D835delins

c.2503_2504delinsAG

176 papers

NM_004119.3

p.D835E

c.2505T>G

175 papers

NM_004119.3

p.D835E

c.2505T>A

1 paper

NM_004119.3

p.D835fs

c.2503_2504fs

630 papers

NM_004119.3

p.D835Y

c.2503G>T

280 papers

NM_004119.3

p.D835H

c.2503G>C

78 papers

NM_004119.3

p.D835N

c.2503G>A

1 paper

NM_004119.3

p.I836fs

c.2506_2507fs

4 papers

NM_004119.3

p.I836F

c.2506A>T