Varaico: Literature-Extracted Genetic Variants

FLT3

2,401 papers

RefSeq Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, whic...

Pfam Domains

igaa 258–343UCSCImmunoglobulin domain

PK_Tyr_Ser-Thraa 610–943UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 3

HGNC Alias Symbols

FLK2; CD135

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004119.3

p.F830L

c.2488T>C

Surrounding Variants

1 paper

NM_004119.3

p.F830I

c.2488T>A

1 paper

NM_004119.3

p.F830L

c.2490T>G

1 paper

NM_004119.3

p.F830L

c.2490T>A

3 papers

NM_004119.3

p.G831R

c.2491G>C

3 papers

NM_004119.3

p.G831R

c.2491G>A

1 paper

NM_004119.3

p.C828*

c.2484T>A

22 papers

NM_004119.3

p.G831E

c.2492G>A

4 papers

NM_004119.3

p.C828S

c.2483G>C

2 papers

NM_004119.3

p.C828R

c.2482T>C

4 papers

NM_004119.3

p.C828S

c.2482T>A

1 paper

NM_004119.3

p.L832W

c.2495T>G

1 paper

NM_004119.3

p.L832F

c.2496G>T