Varaico: Literature-Extracted Genetic Variants

FLT3

2,401 papers

RefSeq Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, whic...

Pfam Domains

igaa 258–343UCSCImmunoglobulin domain

PK_Tyr_Ser-Thraa 610–943UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 3

HGNC Alias Symbols

FLK2; CD135

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004119.3

p.Y726H

c.2176T>C

Surrounding Variants

1 paper

NM_004119.3

p.P727S

c.2179C>T

1 paper

NM_004119.3

p.S724R

c.2172T>G

1 paper

NM_004119.3

p.S724R

c.2172T>A

1 paper

NM_004119.3

p.T728fs

c.2182_2183fs

1 paper

NM_004119.3

p.S724R

c.2170A>C

1 paper

NM_004119.3

p.P727delFs

c.2181delG

1 paper

NM_004119.3

p.F723F

c.2169C>T

2 papers

NM_004119.3

p.Q730*

c.2188C>T

1 paper

NM_004119.3

p.Q730delFs

c.2190delT

1 paper

NM_004119.3

p.H721Y

c.2161C>T

1 paper

NM_004119.3

p.S731L

c.2192C>T

1 paper

NM_004119.3

p.E720K

c.2158G>A