Varaico: Literature-Extracted Genetic Variants

FLT3

2,401 papers

RefSeq Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, whic...

Pfam Domains

igaa 258–343UCSCImmunoglobulin domain

PK_Tyr_Ser-Thraa 610–943UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 3

HGNC Alias Symbols

FLK2; CD135

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004119.3

p.F710S

c.2129T>C

Surrounding Variants

1 paper

NM_004119.3

p.K709_F710delFs

c.2127_2128delAT

1 paper

NM_004119.3

p.H711R

c.2132A>G

2 papers

NM_004119.3

p.K709T

c.2126A>C

1 paper

NM_004119.3

p.K709fs

c.2125_2126fs

2 papers

NM_004119.3

p.R712W

c.2134A>T

1 paper

NM_004119.3

p.E708G

c.2123A>G

1 paper

NM_004119.3

p.R707K

c.2120G>A

1 paper

NM_004119.3

p.R707_E708insT

c.2119_2123ins3

1 paper

NM_004119.3

p.T715A

c.2143A>G

1 paper

NM_004119.3

p.S705N

c.2114G>A

2 papers

NM_004119.3

p.E716Q

c.2146G>C

1 paper

NM_004119.3

p.E716K

c.2146G>A