Varaico: Literature-Extracted Genetic Variants

FLT3

2,401 papers

RefSeq Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, whic...

Pfam Domains

igaa 258–343UCSCImmunoglobulin domain

PK_Tyr_Ser-Thraa 610–943UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 3

HGNC Alias Symbols

FLK2; CD135

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004119.3

p.N701D

c.2101A>G

Surrounding Variants

1 paper

NM_004119.3

p.N701H

c.2101A>C

8 papers

NM_004119.3

p.N701K

c.2103C>G

8 papers

NM_004119.3

p.N701K

c.2103C>A

2 papers

NM_004119.3

p.L699F

c.2095C>T

1 paper

NM_004119.3

p.L703I

c.2107C>A

1 paper

NM_004119.3

p.D698Y

c.2092G>T

11 papers

NM_004119.3

p.D698N

c.2092G>A

1 paper

NM_004119.3

p.R704*

c.2110A>T

1 paper

NM_004119.3

p.R704I

c.2111G>T

26 papers

NM_004119.3

p.G697R

c.2089G>C

7 papers

NM_004119.3

p.G697S

c.2089G>A

1 paper

NM_004119.3

p.S705N

c.2114G>A