Varaico: Literature-Extracted Genetic Variants

FLT3

2,401 papers

RefSeq Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, whic...

Pfam Domains

igaa 258–343UCSCImmunoglobulin domain

PK_Tyr_Ser-Thraa 610–943UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 3

HGNC Alias Symbols

FLK2; CD135

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

9 papers

NM_004119.3

p.Y693C

c.2078A>G

Surrounding Variants

1 paper

NM_004119.3

p.Y693F

c.2078A>T

1 paper

NM_004119.3

p.Y693S

c.2078A>C

3 papers

NM_004119.3

p.Y693N

c.2077T>A

1 paper

NM_004119.3

p.Y693Y

c.2079C>T

2 papers

NM_004119.3

p.C694S

c.2080T>A

1 paper

NM_004119.3

p.E692D

c.2076A>T

2 papers

NM_004119.3

p.C694S

c.2081G>C

1 paper

NM_004119.3

p.E692G

c.2075A>G

1 paper

NM_004119.3

p.E692insFs

c.2074_2075insGG

6 papers

NM_004119.3

p.C694C

c.2082T>C

2 papers

NM_004119.3

p.E692Q

c.2074G>C

1 paper

NM_004119.3

p.E692K

c.2074G>A