Varaico: Literature-Extracted Genetic Variants

FLT3

2,401 papers

RefSeq Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, whic...

Pfam Domains

igaa 258–343UCSCImmunoglobulin domain

PK_Tyr_Ser-Thraa 610–943UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 3

HGNC Alias Symbols

FLK2; CD135

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

24 papers

NM_004119.3

p.N676D

c.2026A>G

Surrounding Variants

1 paper

NM_004119.3

p.N676Y

c.2026A>T

1 paper

NM_004119.3

p.N676H

c.2026A>C

3 papers

NM_004119.3

p.N676I

c.2027A>T

15 papers

NM_004119.3

p.N676S

c.2027A>G

11 papers

NM_004119.3

p.N676T

c.2027A>C

1 paper

NM_004119.3

p.V675A

c.2024T>C

1 paper

NM_004119.3

p.N676N

c.2028C>T

142 papers

NM_004119.3

p.N676K

c.2028C>G

143 papers

NM_004119.3

p.N676K

c.2028C>A

1 paper

NM_004119.3

p.L677fs

c.2029_2030fs

1 paper

NM_004119.3

p.L677delFs

c.2029delG

1 paper

NM_004119.3

p.I674N

c.2021T>A