Varaico: Literature-Extracted Genetic Variants

FLT3

2,401 papers

RefSeq Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, whic...

Pfam Domains

igaa 258–343UCSCImmunoglobulin domain

PK_Tyr_Ser-Thraa 610–943UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 3

HGNC Alias Symbols

FLK2; CD135

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004119.3

p.M659R

c.1976T>G

Surrounding Variants

2 papers

NM_004119.3

p.M659I

c.1977G>T

2 papers

NM_004119.3

p.M659I

c.1977G>C

2 papers

NM_004119.3

p.M659I

c.1977G>A

2 papers

NM_004119.3

p.M659L

c.1975A>T

2 papers

NM_004119.3

p.M659L

c.1975A>C

1 paper

NM_004119.3

p.S660*

c.1979C>G

1 paper

NM_004119.3

p.S660*

c.1979C>A

1 paper

NM_004119.3

p.A657A

c.1971A>G

2 papers

NM_004119.3

p.E661V

c.1982A>T

1 paper

NM_004119.3

p.A657T

c.1969G>A

1 paper

NM_004119.3

p.E656A

c.1967A>C

1 paper

NM_004119.3

p.E656*

c.1966G>T