Varaico: Literature-Extracted Genetic Variants

FLT3

2,401 papers

RefSeq Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, whic...

Pfam Domains

igaa 258–343UCSCImmunoglobulin domain

PK_Tyr_Ser-Thraa 610–943UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 3

HGNC Alias Symbols

FLK2; CD135

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004119.3

p.S653P

c.1957T>C

Surrounding Variants

1 paper

NM_004119.3

p.E654K

c.1960G>A

1 paper

NM_004119.3

p.S652G

c.1954A>G

2 papers

NM_004119.3

p.D651G

c.1952A>G

2 papers

NM_004119.3

p.R655G

c.1963A>G

1 paper

NM_004119.3

p.R655K

c.1964G>A

1 paper

NM_004119.3

p.A650fs

c.1948_1949fs

1 paper

NM_004119.3

p.R655S

c.1965A>T

1 paper

NM_004119.3

p.R655S

c.1965A>C

1 paper

NM_004119.3

p.E656*

c.1966G>T

1 paper

NM_004119.3

p.A650_D651ins9

c.1948_1952ins27

1 paper

NM_004119.3

p.A650T

c.1948G>A

1 paper

NM_004119.3

p.E656A

c.1967A>C