Varaico: Literature-Extracted Genetic Variants

FLT3

2,401 papers

RefSeq Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, whic...

Pfam Domains

igaa 258–343UCSCImmunoglobulin domain

PK_Tyr_Ser-Thraa 610–943UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 3

HGNC Alias Symbols

FLK2; CD135

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004119.3

p.D593A

c.1778A>C

Surrounding Variants

1 paper

NM_004119.3

p.D593V

c.1778A>T

3 papers

NM_004119.3

p.D593G

c.1778A>G

1 paper

NM_004119.3

p.D593ins13

c.1778_1779ins39

1 paper

NM_004119.3

p.D593insFs

c.1778_1779ins16

1 paper

NM_004119.3

p.D593ins8

c.1778_1779ins24

1 paper

NM_004119.3

p.D593ins14

c.1778_1779ins42

1 paper

NM_004119.3

p.D593ins13

c.1778_1779ins39

1 paper

NM_004119.3

p.V592del1

c.1774_1775delAAC

1 paper

NM_004119.3

p.D593fs

c.1777_1778fs

1 paper

NM_004119.3

p.Q577_D593ins5

c.1731_1778dup48

1 paper

NM_004119.3

p.D593_F594ins6

c.1779_1780ins18

1 paper

NM_004119.3

p.D593Fs

c.1779delinsGGTGACCGGCTCCTCAGATAATGAGTACTTCTACGTTGAFs