Varaico: Literature-Extracted Genetic Variants

FLT3

2,401 papers

RefSeq Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, whic...

Pfam Domains

igaa 258–343UCSCImmunoglobulin domain

PK_Tyr_Ser-Thraa 610–943UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 3

HGNC Alias Symbols

FLK2; CD135

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_004119.3

p.Q577_Y589delins

c.1730_1765delinsCCTCCG

Surrounding Variants

1 paper

NM_004119.3

p.Y589ins1

c.1765_1766insCCG

2 papers

NM_004119.3

p.Y589_F590ins12

c.1765_1769ins36

9 papers

NM_004119.3

p.Y589D

c.1765T>G

7 papers

NM_004119.3

p.Y589H

c.1765T>C

2 papers

NM_004119.3

p.Y589N

c.1765T>A

2 papers

NM_004119.3

p.Y589fs

c.1765_1766fs

1 paper

NM_004119.3

p.E588_Y589ins6

c.1764_1765ins18

9 papers

NM_004119.3

p.Y589F

c.1766A>T

1 paper

NM_004119.3

p.Y589C

c.1766A>G

1 paper

NM_004119.3

p.S585_Y589delins

c.1753_1766delinsGC

1 paper

NM_004119.3

p.Y589*

c.1767C>G

1 paper

NM_004119.3

p.Y589fs

c.1765_1766fs