Varaico: Literature-Extracted Genetic Variants

FLT3

2,401 papers

RefSeq Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, whic...

Pfam Domains

igaa 258–343UCSCImmunoglobulin domain

PK_Tyr_Ser-Thraa 610–943UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 3

HGNC Alias Symbols

FLK2; CD135

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004119.3

p.N587K

c.1761T>A

Surrounding Variants

1 paper

NM_004119.3

p.N587insFs

c.1760_1761ins31

1 paper

NM_004119.3

p.N587K

c.1761T>G

2 papers

NM_004119.3

p.E588K

c.1762G>A

1 paper

NM_004119.3

p.S585_N587delFs

c.1755_1761del7

1 paper

NM_004119.3

p.E588fs

c.1762_1763fs

1 paper

NM_004119.3

p.N587S

c.1760A>G

2 papers

NM_004119.3

p.E588V

c.1763A>T

1 paper

NM_004119.3

p.N587D

c.1759A>G

1 paper

NM_004119.3

p.E588ins14

c.1763_1764ins42

1 paper

NM_004119.3

p.D586delFs

c.1758delA

2 papers

NM_004119.3

p.D586E

c.1758T>G

2 papers

NM_004119.3

p.D586E

c.1758T>A