Varaico: Literature-Extracted Genetic Variants

FLT3

2,401 papers

RefSeq Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, whic...

Pfam Domains

igaa 258–343UCSCImmunoglobulin domain

PK_Tyr_Ser-Thraa 610–943UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 3

HGNC Alias Symbols

FLK2; CD135

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004119.3

p.D586N

c.1756G>A

Surrounding Variants

1 paper

NM_004119.3

p.D586fs

c.1756_1757fs

3 papers

NM_004119.3

p.D586Y

c.1756G>T

1 paper

NM_004119.3

p.D586H

c.1756G>C

1 paper

NM_004119.3

p.D586A

c.1757A>C

1 paper

NM_004119.3

p.D586ins4

c.1757_1758ins12

1 paper

NM_004119.3

p.S574_D586ins4

c.1721_1756dup36

1 paper

NM_004119.3

p.S585fs

c.1753_1754fs

2 papers

NM_004119.3

p.D586E

c.1758T>G

2 papers

NM_004119.3

p.D586E

c.1758T>A

1 paper

NM_004119.3

p.S585L

c.1754C>T

1 paper

NM_004119.3

p.S585delFs

c.1753delA

1 paper

NM_004119.3

p.S585ins8

c.1753_1754ins24