Varaico: Literature-Extracted Genetic Variants

FLT3

2,401 papers

RefSeq Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, whic...

Pfam Domains

igaa 258–343UCSCImmunoglobulin domain

PK_Tyr_Ser-Thraa 610–943UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 3

HGNC Alias Symbols

FLK2; CD135

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004119.3

p.Q580R

c.1739A>G

Surrounding Variants

7 papers

NM_004119.3

p.Q580P

c.1739A>C

1 paper

NM_004119.3

p.Q580_V581insFs

c.1740_1741ins7

1 paper

NM_004119.3

p.Q580fs

c.1738_1739fs

1 paper

NM_004119.3

p.Q580_V581ins16

c.1740_1741ins48

1 paper

NM_004119.3

p.L576_Q580del0

c.1728_1739del12

1 paper

NM_004119.3

p.Q580E

c.1738C>G

1 paper

NM_004119.3

p.V579_Q580ins1

c.1737_1738insAGG

1 paper

NM_004119.3

p.Q577_Q580delins

c.1730_1738delinsGGCTCTCCG

2 papers

NM_004119.3

p.V581L

c.1741G>T

1 paper

NM_004119.3

p.V581ins1

c.1741_1742insATT

1 paper

NM_004119.3

p.V581ins13

c.1741_1742ins39

2 papers

NM_004119.3

p.V581L

c.1741G>C