Varaico: Literature-Extracted Genetic Variants

FLT3

2,401 papers

RefSeq Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, whic...

Pfam Domains

igaa 258–343UCSCImmunoglobulin domain

PK_Tyr_Ser-Thraa 610–943UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 3

HGNC Alias Symbols

FLK2; CD135

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004119.3

p.M578L

c.1732A>C

Surrounding Variants

1 paper

NM_004119.3

p.M578L

c.1732A>T

4 papers

NM_004119.3

p.M578T

c.1733T>C

2 papers

NM_004119.3

p.S574_M578delins

c.1721_1733delinsACCCGCC

1 paper

NM_004119.3

p.Q577Q

c.1731G>A

1 paper

NM_004119.3

p.M578I

c.1734G>T

1 paper

NM_004119.3

p.M578ins2

c.1733_1734ins6

1 paper

NM_004119.3

p.M578I

c.1734G>C

2 papers

NM_004119.3

p.M578I

c.1734G>A

1 paper

NM_004119.3

p.V579L

c.1735G>T

1 paper

NM_004119.3

p.V579L

c.1735G>C

2 papers

NM_004119.3

p.V579I

c.1735G>A

1 paper

NM_004119.3

p.Y572_V579delins

c.1714_1735delinsCCCT