Varaico: Literature-Extracted Genetic Variants

FLT3

2,401 papers

RefSeq Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, whic...

Pfam Domains

igaa 258–343UCSCImmunoglobulin domain

PK_Tyr_Ser-Thraa 610–943UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 3

HGNC Alias Symbols

FLK2; CD135

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004119.3

p.D469E

c.1407C>A

Surrounding Variants

1 paper

NM_004119.3

p.D469E

c.1407C>G

1 paper

NM_004119.3

p.D469fs

c.1405_1406fs

1 paper

NM_004119.3

p.D469N

c.1405G>A

1 paper

NM_004119.3

p.S468delFs

c.1404delT

1 paper

NM_004119.3

p.K470R

c.1409A>G

1 paper

NM_004119.3

p.S468L

c.1403C>T

1 paper

NM_004119.3

p.S468*

c.1403C>G

1 paper

NM_004119.3

p.S468*

c.1403C>A

2 papers

NM_004119.3

p.S471C

c.1412C>G

1 paper

NM_004119.3

p.P472S

c.1414C>T

1 paper

NM_004119.3

p.N473Y

c.1417A>T

1 paper

NM_004119.3

p.K465M

c.1394A>T