Varaico: Literature-Extracted Genetic Variants

FLT3

2,401 papers

RefSeq Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, whic...

Pfam Domains

igaa 258–343UCSCImmunoglobulin domain

PK_Tyr_Ser-Thraa 610–943UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 3

HGNC Alias Symbols

FLK2; CD135

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_004119.3

p.T463T

c.1389C>G

Surrounding Variants

1 paper

NM_004119.3

p.T463A

c.1387A>G

2 papers

NM_004119.3

p.W462*

c.1386G>A

2 papers

NM_004119.3

p.W462*

c.1385G>A

1 paper

NM_004119.3

p.S461delFs

c.1382_1383delAG

1 paper

NM_004119.3

p.K465M

c.1394A>T

1 paper

NM_004119.3

p.S461fs

c.1381_1382fs

1 paper

NM_004119.3

p.S461F

c.1382C>T

1 paper

NM_004119.3

p.P460Q

c.1379C>A

1 paper

NM_004119.3

p.S468L

c.1403C>T

1 paper

NM_004119.3

p.S468*

c.1403C>G

1 paper

NM_004119.3

p.S468*

c.1403C>A

1 paper

NM_004119.3

p.D469N

c.1405G>A