Varaico: Literature-Extracted Genetic Variants

FLT3

2,401 papers

RefSeq Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, whic...

Pfam Domains

igaa 258–343UCSCImmunoglobulin domain

PK_Tyr_Ser-Thraa 610–943UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

fms related receptor tyrosine kinase 3

HGNC Alias Symbols

FLK2; CD135

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

45 papers

NM_004119.3

p.S451F

c.1352C>T

Surrounding Variants

2 papers

NM_004119.3

p.S451C

c.1352C>G

1 paper

NM_004119.3

p.A450delFs

c.1350delC

1 paper

NM_004119.3

p.S451fs

c.1351_1352fs

3 papers

NM_004119.3

p.A450V

c.1349C>T

1 paper

NM_004119.3

p.A450G

c.1349C>G

2 papers

NM_004119.3

p.F453L

c.1357T>C

1 paper

NM_004119.3

p.Q449H

c.1347G>T

1 paper

NM_004119.3

p.A447_Q449delFs

c.1340_1346del7

1 paper

NM_004119.3

p.Q449*

c.1345C>T

2 papers

NM_004119.3

p.F453L

c.1359C>G

2 papers

NM_004119.3

p.F453L

c.1359C>A

1 paper

NM_004119.3

p.Q449K

c.1345C>A